Staff Profile

Teaching Areas & Research Interests

• Teaching Areas: Anatomy and physiology
• Research Interests: Translational research of pipeline compounds in cancer therapy, Cancer cell biology, Regenerative medicine

Selected Publications

Journal Articles

• Ng, L., Li, H. S., Man, A. T., Chow, A. K., Foo, D. C., Lo, O. S., Pang, R. W., Law, W. L. (2022) High Expression of a Cancer Stemness-related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) is Associated with Poor Prognosis of Colorectal Cancer Patients. Cells, 11(11),1852.
• Ng, L., Wong, S. K., Huang, Z., Lam, C. S., Chow, A. K., Foo, D. C., Lo, O. S., Pang, R. W., Law, W. L. (2022) CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling. International Journal of Molecular Sciences, 23(3), 1181.
• Chow, A. K., Yau, W. L. S., Ng, L. (2020) Novel Molecular Targets in Hepatocellular Carcinoma. World Journal of Clinical Oncology, 11(8), 589-605.
• Ng, L., Kwan, V., Chow, A. K, Yau, T. C., Poon, R. T., Pang, R., Law, W. L. (2019) Overexpression of Pin1 and Rho Signaling Partners Correlates with Metastatic Behavior and Poor Recurrence-free Survival of Hepatocellular Carcinoma Patients. BMC Cancer, 19, 713-720.
• Ng, L., Chow, A. K., Man, J. H., Yau, T. C., Wan, T. M., Lyer, D. N., Kwan, V. H., Poon, R. T., Pang, R. W., Law, W. L. (2018) Suppression of Slit3 Induces Tumor Proliferation and Chemoresistance in Hepatocellular Carcinoma through Activation of GSK3β / β-catenin Pathway. BMC Cancer, 18(1):621-634.
• Cheung, A. H., Lyer, D. N., Lam, C. S., Ng, L., Wong, S. K. M., Lee, H. S., Wan, T., Man, J., Chow, A. K., Poon, R. T., Pang, R., Law, W. L. (2017) Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis. International journal of molecular sciences, 18(6):1106.
• Lam, C. S., Ng, L., Chow, A. K., Wan, T. M., Yau, S., Cheng, N. S., Wong, S. K., Man, J. H., Lo, O. S., Foo, D. C., Poon, J. T., Pang, R. W., Law, W. L. (2017) Identification of microRNA 885-5p as a Novel Regulator of Tumor Metastasis by Targeting CPEB2 in Colorectal Cancer. Oncotarget, 8(16):26858-26870.
• Ng, L., Wan, T. M., Man, J. H., Chow, A. K., Iyer, D., Chen, G., Yau, T. C., Lo, O. S., Foo, D. C., Poon, J. T., Leung, W. K., Pang, R. W., Law, W. L. (2017) Identification of Serum miR-139-3p as a Non-invasive Biomarker for Colorectal Cancer. Oncotarget, 8(16):27393-27400.
• Chow, A. K., Yau, T. C., Ng, L., Chu, A. C., Law, W. L., Poon, R. T., Pang, R. (2015) A Preclinical Study on the Combination Therapy of Everolimus and Transarterial Chemoembolization in Hepatocellular Carcinoma. American Journal of Cancer Research, 5(8):2376-86.
• Ng, L., Wan, T. M., Chow, A. K., Iyer, D., Man, J., Chen, G. H., Yau, C. C., Lo, O. S., Foo, C. C., Poon, J. T., Poon, T. P., Pang, R., Law, W. L. (2015) Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-like Properties in Human Colorectal Cancer. Stem Cells International, 274892.
• Ng, L., Wan, T. M., Lam, C. S., Chow, A. K., Wong, S. K., Man, J. H., Li, H. S., Cheng, N. S., Pak, R. C., Cheung, A. H., Yau, T. C., Lo, O. S., Foo, D. C., Poon, J. T., Poon, R. T., Pang, R. W., Law, W. L. (2015) Post-operative Plasma Osteopontin Predicts Distant Metastasis in Human Colorectal Cancer. PLoS One, 10(5):e0126219.
• Chow, A. K., Cheng, N. S., Lam, C. S., Ng, L., Wong, S. K., Wan, T. M., Man, J. H., Cheung, A. H., Yau, T. C., Poon, J. T., Law, W. L., Pang, R. W. (2015) Preclinical Analysis of the Anti-tumor and Anti-metastatic Effects of Raf265 on Colon Cancer Cells and CD26+ Cancer Stem Cells in Colorectal Carcinoma. Molecular Cancer,14:80.
• Wan, T. M., Lam, C. S., Ng, L., Chow, A. K., Wong, S. K., Li, H. S., Man, J. H., Lo, O. S., Foo, D., Cheung, A., Yau, T., Poon, J. T., Poon, R. T., Law, W. L., Pang, R. W. (2014) The Clinicopathological Significance of miR-133a in Colorectal Cancer. Disease Markers, 2014:919283.
• Or, Y. Y., Chow, A. K., Ng, L., Fan, S. T., Yau, T. C., Poon, R. T., Pang, R. W. (2014) Survivin Depletion Inhibits Tumor Growth and Enhances Chemosensitivity in Hepatocellular Carcinoma. Molecular Medicine Reports, 10(4), 2025-2030.
• Lam, C. S., Cheung, A. H., Wong, S. K., Wan, T. M., Ng, L., Chow, A. K., Cheng, N. S., Pak, R. C., Li, H. S., Man, J. H., Yau, T. C., Lo, O. S., Poon, J. T., Pang, R. W., Law, W. L. (2014) Prognostic Significance of CD26 in Patients with Colorectal Cancer. PLoS One, 28;9(5):e98582.
• Chow, A. K., Ng, L., Lam, C. S., Wong, S. K., Wan, T. M., Cheng, N. S., Yau, T. C., Poon, R. T., Pang, R. W. (2013) The Enhanced Metastatic Potential of Hepatocellular Carcinoma (HCC) Cells with Sorafenib Resistance. PLOS one, 11;8(11):e78675.
• Cheng, C. W., Chow, A. K., Pang, R. W., Fok, E. W., Kwong, Y. L., Tse, E. (2013) Pin1 Inhibits Apoptosis in Hepatocellular Carcinoma Through Modulation of the Antiapoptotic Function of Survivin. American Journal of Pathology, 182(3): 765-75.
• Yau, W. L., Lam, C. S., Ng, L., Chow, A. K., Chan, S. T, Chan, J. Y., Wo, J. Y., Ng, K. T., Man, K., Poon, R. T., Pang, R. W.(2013) Over-expression of miR-106b Promotes Cell Migration and Metastasis in Hepatocellular Carcinoma by Activating Epithelial-mesenchymal Transition Process. PLOS one, 8(3): e57882.
• Ng, L., Poon, R. T., Yau, S., Chow, A. K., Lam, C. S., Li, H. S., Yau, T. C., Law, W. L., Pang, R. (2013) Suppression of Actopaxin Impairs Hepatocellular Carcinoma Metastasis through Modulation of Cell Migration and Invasion. Hepatology, 58(2), 667-679.
• Chow, A. K., Ng, L., Li, S. H., Cheng, C. W., Lam, C. S., Yau, T. C., Cheng, P. N., Fan, S. T., Poon, R. T., Pang, R. W. (2012) Anti-Tumor Efficacy of a Recombinant Human Arginase in Human Hepatocellular Carcinoma. Current Cancer Drug Targets, 12(9):1233-43.
• Pang, R., Law, W. L., Chu, A. C. Y., Poon, J. T., Lam, C. S. C., Chow, A. K., Ng, L., Cheung, L. W. H., Lan, X. R., Lan, H. Y., Tan, V. P. Y., Yau, T. C., Poon, R. T., Wong, B. C. Y. (2010) A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer. Cell Stem Cell, 6:603-615.

Further Information

Link to Google Scholar page

Modified Date: 02 Jun, 2023
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