Biography
I am a trained Statistician and an Honorary Professor at the Department of Statistics & Actuarial Science of the University of Hong Kong. My main research area includes Survival Analysis, Biostatistics, Statistical Epidemiology and Public Health. On the theoretical or methodological side, I am interested in developing new statistical models and methods for the analysis of survival data (univariate or complex multivariate) with various censoring mechanisms (right censored, grouped or discrete survival data, current status data, interval-censored data, or more generally data with incomplete observations like survival data with a cure fraction). Analysis of survival data has been a very interesting and challenging area. I have publications in some high standard international referred journals like Journal of the American Statistical Association, Biometrika, Biometrics, Statistical Methods in Medical Research and Statistics in Medicine.
My other major research activity is on Medical Statistics. To distinguish myself as a Biostatistician working in the area of Medical Statistics, I have established a good rapport with some researchers from the field of Medicine, and have been involved in various medical research projects in Family Medicine, Public Health, Gastroenterology, Cardiology, Osteoporosis, Endocrinology, Obstetrics, Epidemiology, Health Economics and Dental Research. My special role is to provide statistical advice in the planning, design and data analysis of some controlled clinical trials and/or questionnaires designs. My goal is to advocate and promote the appropriate and efficient use of statistical methods so that the research projects can be conducted at the highest scientific standard, and to provide valid and timely answers to issues affecting health. I consider this type of multidisciplinary research very important, and I look forward to learning more from the medical researchers and being inspired by the data sets so as to develop more useful statistical models and methods to answer important clinical problems that affect health.
Another area of interest is statistical epidemiology with particular interest in infectious disease and estimation of vaccine efficacy. I have been collaborating with researchers from the Center for Quantitative Medicine of Duke-NUS Medical School, Singapore in this area for over 10 years. I am an Adjunct Associate Professor, an honorary appointment of the Center since 2018, in view of my contribution to some projects in this area.
Teaching Areas & Research Interests
Selected Publications
Journal Articles
- “Joint Analysis of Time-Varying Effect of Vaccine and Antiviral Drug for Prevention Severe Complications and Mortality.” J. Jiang, K.F. Lam, E.H.Y. Lau, G. Yin, Y, Lin, B.J. Cowling. Scientific Reports 15(1), 2205, 5640.
- “High-dimensional Feature Screening for Nonlinear Associations with Survival Outcome Using Restricted Mean Survival Time.” Y. Chen, K.F. Lam, Z. Liu. STAT 13(2), 2024, e673.
- “Sample Size Calculation for Multi-arm Parallel Design with Restricted Mean Survival Time.” Y. Chen, K.F. Lam, J. Xu. Statistical Methods in Medical Research 33(1), 2024, pp130-147. DOI:10.1177/09622802231219852
- “A Semiparametric Joint Model for Cluster Size and Subunit-Specific Interval-Censored Outcomes.” C.Y. Lee, K.Y. Wong, K.F. Lam, D. Bandyopadhyay. Biometrics, 2023, 79, pp2010-2022. DOI: 10.1111/biom.13795
- “A Novel Method to Monitor COVID-19 Fatality Rate in Real-time, a Key Metric to Guide Public Health Policy.” Y. Qu, C.Y. Lee, K.F. Lam. Scientific Reports 12(1), 2022, 18277.
- “A Sequential Test to Compare the Real-time Fatality Rates of a Disease Among Multiple Groups with an Application to COVID-19 Data.” Y. Qu, C.Y. Lee, K.F. Lam. Statistical Methods in Medical Research, 31, 2022, pp348-360.
- “A Semiparametric Regression Cure Model with Current Status Data”. K.F. Lam, H. Xue. Biometrika, 92, 2005, pp 573-586.
- “Sieve Maximum Likelihood Estimator for Semiparametric Regression Models with Current Status Data”. H. Xue, K.F. Lam & G. Li. Journal of the American Statistical Association, 99, 2004, pp346-356.
- “A Class of Tests for Equality of k Cause Specific Hazard Rates in a Competing Risks Model”. K.F. Lam. Biometrika. 85 (1), 1998, pp179-188.
- “A Marginal Likelihood Approach to Estimation in Frailty Models”. K.F. Lam & A.Y.C. Kuk. Journal of the American Statistical Association. 92, 1997, pp 985-990.
- “Estimation of Trajectory of COVID-19 Vaccines Effectiveness Against Infection.” J. Jiang, K.F. Lam, E.H.Y. Lau, G. Yin, Y. Lin, B.J. Cowling. 2025. Vaccine 55, 127067.
- “Protection and Waning of Vaccine-Induced, Natural and Hybrid Immunity to SARS-CoV-2 in Hong Kong.” J. Jiang, K.F. Lam, E.H.Y. Lau, G. Yin, Y. Lin, B.J. Cowling. 2025. Expert Review Vaccines. 24(1), 252-260.
- “Development of a Territory-wide Household-based Composite Index for Measuring Relative Distribution of Households by Economic Status in Individual Small Areas throughout Hong Kong.” E.L.H. Tsui, P.L.H. Yu, K.F. Lam, K.K.Y. Poon, A.C.M. Ng, K.Y. Cheung, W. Li, M.L.H. Leung, D.H.Y. Lam, J.L.Y. Cheung, S.P.W. Ng. 2024. BMC Public Health 24, 3555.
- “Coping with Peer Suicidality, Help-Seeking Intentions, and Suicidal Attitudes among Asian Adolescents: A Mixed-Methods Study in Hong Kong.” S.S. Chen, T.P. Lam, K.F. Lam, T.L. Lo, D.V.K. Chao, K.Y. Mak, E.W.W. Lam, W.S. Tang, H.Y. Chan, PS.F. Yip. 2025. Child and Adolescent Mental Health 30 (1), pp.21-33.
- “Joint Analysis of Vaccination Effectiveness and antiviral drug effectiveness for COVID-19: a causal inference approach.” Y.Y.H. Cheung, E.H.Y. Lau, G. Yin, Y. Lin, J. Jiang, B.J. Cowling, K.F. Lam. 2024. International Journal of Infectious Diseases, 143, 107012.
- “Effectiveness of Vaccines and Antivirals in Preventing Severe and Fatal COVID-19 in Hong Kong.” Y.Y.H. Cheung, E.H.Y. Lau, G. Yin, Y. Lin, B.J. Cowling, K.F. Lam. Emerging Infectious Diseases, 2024, 30(1), pp.70-78. DOI: 10.3201/eid3001.230414
- “A Long Non-Coding RNA Signature in Glioblastoma Multiforme Predicts Survival.” X. Zhang, S. Sun, K.F. Lam, K.M.Y. Kiang, J.K.S. Pu, A.S.W. Ho, W.M. Lui, C.F. Fung T.S. Wong. G.K.K. Leung. Neurobiology of Disease, 58, 2013, pp123-131. DOI: 10.1016/j.nbd.2013.05.011
- “Effect of Esomeprazole versus Famotidine on Platelet Inhibition by Clopidogrel: a Double-blind Randomized Trial”. P. Tunggal, F.H. Ng, K.F. Lam, F.K. Chan, Y.K. Lau. American Heart Journal 162(5), 2011, pp870-874.
- . “Prevalence of Colorectal Neoplasm Among Patients with Newly Diagnosed Coronary Artery Disease” A.O.O Chan, M.H. Jim, K.F. Lam, J. Morris, D.C.W. Siu, T. Tong, F.H. Ng, S.Y. Wong, W.M. Hui, C.K. Chan, K.C. Lai, T.K. Cheung, P. Chan, G. Wong, M.F. Yuen, Y.K. Lau, S. Lee, M.L. Szeto, B.C.Y. Wong, S.K. Lam. Journal of the American Medical Association, 298(12) 2007 pp1412-1419.
- “Association Between Helicobacter Pylori Infection and Interleukin 1beta Polymorphism Predispose to CpG Island Methylation in Gastric Cancer”. A.O.O Chan, K.M. Chu, C. Huang, K.F. Lam, S.Y. Leung, Y.W. Sun, S. Ko, H.H. Xia, C.H. Cho, W.M. Hui, S.K. Lam, A. Rashid, B.C.Y. Wong. GUT, 56(4) 2007 pp595-597.
- “Comparison of Esophageal Acid Exposure Distribution Along the Esophagus Among the Different Gastroesophageal Reflux Disease (GERD) Groups”. R. Dickman, J.M. Bautista, W.M. Wong, R. Bhatt. J.N. Beeler, I. Malagon, S. Risner-Adler, K.F. Lam and R. Fass. American Journal of Gastroenterology, 101(11) 2006 pp2463-2469.
Further Information
Link to Google Scholar page
Modified Date: 15 Aug, 2025
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